Associate Principal Scientist - Cellular Pharmacology and Lead Discovery
Company: MSD Malaysia
Location: Rahway
Posted on: October 19, 2024
Job Description:
Associate Principal Scientist - Cellular Pharmacology and Lead
DiscoveryJob DescriptionOur company's Research Laboratories in
South San Francisco is seeking an Associate Principal Scientist
with strong expertise in translational cell models, mechanistic
pharmacology, and biomarker and lead discovery to join our
Quantitative Biosciences (Pharmacology) department. The successful
candidate will be responsible for the design, execution, and
interpretation of complex in vitro/ex vivo assays and mechanistic
experimentation to advance early drug discovery projects from
target concept through lead optimization. The candidate will work
closely with a team of multidisciplinary scientists to enable model
development, assay execution and screening, as well as mechanistic
studies to advance a diverse drug discovery pipeline targeting
obesity, immune-metabolic, and cardiovascular disorders. In
addition, this role will participate in novel technology
evaluation, business development diligence, and internal/external
collaborations. We value rigorous scientific exploration,
creative-thinking, teamwork, and transparent communication. If you
are a highly motivated individual and team player with a strong
desire to impact cardiovascular and metabolic drug discovery, we
invite you to consider joining our team.Key responsibilities:
- Support pharmacology strategies targeting obesity,
immuno-metabolic, and cardiovascular diseases to enable a robust
drug discovery pipeline.
- Develop and implement potency, selectivity, and mechanistic
assays to characterize molecules targeting diverse targets,
pathways, and areas of biology.
- Design and execute complex cell assays using diverse model
systems and advanced technologies to support translational research
and biomarker discovery.
- Serve as a core member in matrixed project teams and governance
committees to enable pharmacology strategy and provide robust
scientific and technical support.
- Ensure high-quality and timely data generation, analysis, and
reporting to project teams, governance bodies, and regulatory
agencies.
- Drive scientific innovation and champion new enabling
technologies and methods to enhance functional capabilities and
productivity.
- Collaborate extensively across our company's network and with
external partners to drive project progression toward key
milestones and contribute to business development
diligence.Qualifications:Education:
- Ph.D. in Pharmacology, Cell Biology or relevant scientific
discipline with a minimum of five (5) years of drug discovery
experience in a biotech or pharmaceutical setting.Required
Experience and Skills:
- Solid understanding of drug discovery strategies and processes
from target identification and validation to preclinical candidate
selection.
- Demonstrated quantitative pharmacology expertise with
accompanying knowledge in cardiovascular and metabolic disease
pathways and mechanisms.
- Highly skilled in physiologically relevant assay development
(primary cells, co-culture, etc.) for cardiometabolic disease
modeling, translational pharmacology, and biomarker discovery.
- Experienced in lead optimization and SAR support, plate-based
detection methods, and the utilization of advanced lab
automation.
- Proficiency with automated data processing, curve fitting, and
visualization software tools.
- Excellent organization and communication skills with a strong
growth mindset.
- Demonstrated ability to multi-task and work collaboratively in
a cross-functional team environment to influence strategy and
tactics to advance drug discovery.
- Proven record of publications in peer-reviewed journals and/or
patent literature.Preferred Experience and Skills:
- Prior working experience with multiple therapeutic modalities
(small molecule, peptide, biologics, etc.).
- Prior experience of leading drug discovery projects and/or
mentoring junior staff.NOTICE FOR INTERNAL APPLICANTSIn accordance
with Managers' Policy - Job Posting and Employee Placement, all
employees subject to this policy are required to have a minimum of
twelve (12) months of service in current position prior to applying
for open positions.If you have been offered a separation benefits
package, but have not yet reached your separation date and are
offered a position within the salary and geographical parameters as
set forth in the Summary Plan Description (SPD) of your separation
package, then you are no longer eligible for your separation
benefits package. To discuss in more detail, please contact your
HRBP or Talent Acquisition Advisor.Employee Status:
RegularRelocation: Domestic/InternationalVISA Sponsorship:
YesTravel Requirements: 10%Shift: 1st - DayJob Posting End Date:
10/31/2024Our company is a global health care leader with a
diversified portfolio of prescription medicines, vaccines and
animal health products. The difference between potential and
achievement lies in the spark that fuels innovation and
inventiveness; this is the space where we have codified our legacy
for over a century. Our success is backed by ethical integrity,
forward momentum, and an inspiring mission to achieve new
milestones in global healthcare.
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Keywords: MSD Malaysia, Fairfield , Associate Principal Scientist - Cellular Pharmacology and Lead Discovery, Other , Rahway, Connecticut
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